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Finally, it is noteworthy that following mTBI, the cortex presents with very early alterations in mitochondrial bioenergetics (Gilmer et al., 2009)

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For instance, Assessing 8-OHdG levels provides valuable insights into the extent of oxidative damage, aiding in disease prognosis and therapeutic strategies (187)

The PCA of the nine adjusted metabolite concentration values (glutathione, glutamate, and glutamine in each of the three voxels, ACC, Insula, and Visual) resulted in three components with an eigenvalue greater than 1

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